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KMID : 0613820190290050607
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Journal of Life Science
2019 Volume.29 No. 5 p.607 ~ p.613
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The Effects of Either Chrysin or Moderate Exercise on Inflammasome and Thermogenic Markers in High Fat Fed Mice
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Lee Young-Ran
Park Hee-Geun
Lee Wang-Lok
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Abstract
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The purpose of this study was to investigate the effects of either chrysin or exercise on the inflammasome and thermogenic markers in the livers of high-fat fed mice. C57BL/6 mice were randomly assigned to four groups: normal diet control (NC; n=5), high-fat diet control (HC; n=5), high-fat diet with chrysin (Hch; n=5), and high-fat diet with moderate exercise (HME; n=5). The mice were fed a high-fat diet (60% of calories from fat) or normal diet (18% of calories from fat). Chrysin was supplemented orally as 50mg/kg/day dissolved in a 0.1ml solution of dimethyl sulfoxide. The exercised mice ran on a treadmill at 12-20 m/min for 30-60 min/day, 5 times/week, for 16 weeks. After the intervention, the epididymal fat and liver weights were significantly decreased in the HME group compared with HC and Hch groups. The adipocyte size was effectively decreased in the Hch and HME groups compared with the HC group. The inflammasome markers NLRP3, IL-1β, and caspase1 were significantly decreased in the Hch and HME groups compared with the HC group. The thermogenic markers PGC-1α and BMP7 were significantly lower in the HC than in the NC group. However, the HME group showed an increase in the thermogenic markers. In conclusion, chrysin and moderate exercise have positive effects on obese metabolic complications induced by high-fat diets by reducing inflammasome genes. However, chrysin supplementation had no effect on thermogenic gene expression. Moderate exercise would therefore seem to be more effective in controlling obesity-induced metabolic deregulation.
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KEYWORD
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Browning marker, chrysin, exercise, inflammasome, obese
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